Pharmaceutical formulations with mini tablets is not a recent development.
For certain areas of indications, this type of administration has been used
successfully for almost 20 years.

Mini tablets are currently the focus of development in pharmaceutical
preparations aimed at the specific requirements of child-friendly drug delivery.
For this patient group in particular the possibility of administering precisely
proportioned minute dosages may be highly beneficial.

Of particular interest are scientific publications from 1998 onwards, which,
among other things, study the unfavourable densification behaviour of
certain drugs and which indicate that higher concentrations of drugs that are
difficult to compress, influence the properties of mini tablets less negatively
than those of normally sized tablets.

In the context of studying and describing the properties of mini tablets
we would like to refer to a number of theses written at the University of
Hamburg under the supervision of Prof. Jobst B. Mielck.