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• thanks
to the increased surface in relation to volume, the drug can
be released more efficiently
• a controlled release process, as in depot/delayed
drug formulations
or in formulations which consist of initial and maintenance doses
are
usually based on release through a retarding film coating. If this
film is
not completely intact, drug release is no longer controlled.
Simultaneous perforation of the film in a large number of mini tablets
is
unlikely. Thus, the release process can be controlled with greater
certainty.
• by combining differently dosed mini tablets, it is possible
to achieve
several different releases with one formulation.
• due to the significantly smaller dimensions of the mini tablets
in
comparison to a normally sized tablet, the mini tablets pass through
the stomach at a more even rate. As a result, the absorption, and
therefore also the concentration of the drug in the blood can be
more
easily reproduced than in the case of a normally sized tablet. |